DoD FY11 Prostate Cancer Research Program Laboratory-Clinical Transition Award — Defense Health Agency Contracting Activity - DHACA funding opportunity
Defense Health Agency Contracting Activity - DHACA · Federal agency

DoD FY11 Prostate Cancer Research Program Laboratory-Clinical Transition Award

The PCRP Laboratory-Clinical Transition Award mechanism was introduced in FY07. Since then, 49 applications have been received, and 9 have been recommended for funding. The Laboratory-Clinical Transition Award supports p...

63
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Award $0 Deadline 5406 days ago Location Alabama Type grant Level Federal Closed posted May 5, 2011
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Funding amount: total funding pool ~$2,400,000.
  • Next deadline: September 1, 2011.
  • Issued by: Defense Health Agency Contracting Activity - DHACA.
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The “key facts” mode pulls structured fields directly from the official source posting (amount, deadline, eligibility tags). The AI mode adds a short plain-English narrative on top, generated from the same source. Always verify with the agency before applying.

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Award amount
$0
Deadline
5406 days ago
Sep 1, 2011
Total pool
$2.4M

About this opportunity

The PCRP Laboratory-Clinical Transition Award mechanism was introduced in FY07. Since then, 49 applications have been received, and 9 have been recommended for funding. The Laboratory-Clinical Transition Award supports product-driven preclinical studies of promising lead agents that have the potential to revolutionize prostate cancer clinical care. This award is intended to fund Principal Investigators (PIs) who lack support to conduct the preclinical studies needed to advance lead agents to human testing. The goal of this award is the generation of pharmacology and toxicology data for inclusion in a Food and Drug Administration (FDA) Investigational New Drug (IND) application and/or (new for FY11) current Good Manufacturing Practice (cGMP) production of the lead agent(s). Agents supported by this award mechanism are expected to have high potential for commercial licensing for continued development and clinical use. The PI must provide a transition plan (including potential funding and resources) showing how the product will progress to clinical trials and/or delivery to market after the completion of the PCRP award. Applicants are expected to have a validated target, and to have identified either one lead agent or a limited number of lead agents for optimization before applying for this award. In addition, the PI should present data establishing the mechanism of action of the lead agent(s) on the target. Lead agents are defined as novel chemical therapeutics or imaging agents, that have potential clinical application to prostate cancer. Examples of lead agents include, but are not limited to: novel imaging contrast agents. Applications must include preliminary data relevant to the lead agent(s) under development. Any preliminary data provided should be from the laboratory of the PI or member(s) of the collaborating team. Preliminary data must document target availability and distribution in relevant human tissues, and must provide substantive information from model systems that supports the potential efficacy of the lead agent(s) in humans. In addition, applications must describe a statistical/analytical plan(s) to support the proposed studies. These analyses must be consistent with current FDA guidance. The National Cancer Institute (NCI) has constructed developmental pathways for translational research that may be useful for designing translational research studies for support under this mechanism. These pathways are comprehensive and span the entire translational research continuum from discovery of a target to clinical trials http://www.cancer.gov/images/trwg/ Developmental-Pathway-Agent-Drug_Biologics.pdf). All applications for the Laboratory-Clinical Transition Award are highly recommended to address one of the FY11 PCRP overarching challenges. The PCRP seeks to fund projects from the wide spectrum of basic to clinical research; however, if the proposed project does not address one of the overarching challenges, the application should provide a description to justify how the project will nevertheless address a critical need in the field of prostate cancer research and/or patient care. Studies proposed under this award may include, but are not limited to: � Comparative activity/efficacy testing to optimize a lead agent and/or define a single lead agent from a limited library of candidates. Such studies must be completed within 12 months of the start date of the award. If the studies are not completed within 12 months of award initiation, the government reserves the right to terminate the award.

Funding agency

Defense Health Agency Contracting Activity - DHACA
Federal agency

Tags

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Who can apply

Eligibility details aren't on file yet — check the agency source link in the Documents tab for the latest rules.

Geographic eligibility

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Georgia
  • Hawaii
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • North Dakota
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Rhode Island
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming
  • District of Columbia

How to apply

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Source documents

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Canonical NOFO, application packet, and forms
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Citation details

Source systemgrants.gov
Source ID92054
PostedMay 5, 2011

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