DoD FY13 Prostate Cancer Laboratory-Clinical Transition Award — Defense Health Agency Contracting Activity - DHACA funding opportunity
Defense Health Agency Contracting Activity - DHACA · Federal agency

DoD FY13 Prostate Cancer Laboratory-Clinical Transition Award

The PCRP Laboratory - Clinical Transition Award (LCTA) mechanism was introduced in FY07. Since then, 95 applications have been received, and 12 have been recommended for funding. The LCTA supports product-driven preclini...

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Award $0 Deadline 4637 days ago Location Alabama Type grant Level Federal Closed posted May 13, 2013
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Funding amount: total funding pool ~$4,800,000.
  • Next deadline: October 9, 2013.
  • Issued by: Defense Health Agency Contracting Activity - DHACA.
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The “key facts” mode pulls structured fields directly from the official source posting (amount, deadline, eligibility tags). The AI mode adds a short plain-English narrative on top, generated from the same source. Always verify with the agency before applying.

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Award amount
$0
Deadline
4637 days ago
Oct 9, 2013
Total pool
$4.8M

About this opportunity

The PCRP Laboratory - Clinical Transition Award (LCTA) mechanism was introduced in FY07. Since then, 95 applications have been received, and 12 have been recommended for funding. The LCTA supports product-driven preclinical studies of promising lead agents or medical devices that have the potential to revolutionize prostate cancer clinical care. This award is intended to fund Principal Investigators (PIs) who lack support to conduct the preclinical studies needed to advance lead agents or medical devices to human testing, as follows: Lead Agents: It is anticipated that lead agent development projects supported by this award will be generating pharmacology and toxicology data in preclinical studies for inclusion in a Food and Drug Administration (FDA) Investigational New Drug (IND) application and/or current Good Manufacturing Practice (cGMP) production. Applicants are expected to have a validated target and to have identified either one lead agent (or a limited number of lead agents for optimization) before applying for this award. In addition, the PI should present data establishing the mechanism of action of the lead agent on the target or preliminary data demonstrating effectiveness (including sensitivity and specificity). Lead agents are defined as novel biological and molecular or chemical therapeutic or imaging agents having potential clinical application to prostate cancer. Examples of lead agents include, but are not limited to, novel contrast agents, and others. Medical Devices: Projects to be supported by this award will test medical devices in preclinical studies with the intent for FDA Investigational Device Exemption (IDE) application and/or cGMP production of the medical device. As appropriate, the PI should present preliminary data demonstrating effectiveness (including sensitivity and specificity) for the medical device. Examples of medical devices include, but are not limited to, diagnostic or prognostic tests ( microfluidic device, genomic and genetic microarray devices), imaging devices, and other medical technology. Lead agents or medical devices supported by this award are expected to have high potential for commercial licensing for continued development and clinical use. The PI must provide a transition plan (including potential funding and resources) to describe how the product will progress to clinical trials and/or delivery to market after the completion of the PCRP award. The PCRP strongly encourages investigators to leverage existing resources with commercial partners to increase potential gains in translating preclinical research outcomes for continued development and clinical application. Applications that demonstrate cost-sharing with commercial partners are particularly encouraged. Applications must include strong scientific rationale and preliminary data relevant to the lead agent or medical device under development. Preliminary data must document target availability and distribution in relevant human tissues and must provide substantive information from model systems that supports the potential efficacy of the lead agent or medical device in humans. In addition, applications must describe a statistical/analytical plan to support the proposed studies, if applicable. These analyses must be consistent with current FDA guidance. The National Cancer Institute has constructed developmental pathways for translational research that may be useful for designing translational research studies for support under the LCTA mechanism. These pathways are comprehensive and span the entire translational research continuum from discovery of a target to clinical trials (http://www.cancer.gov/images/trwg/ Developmental-Pathway-Agent-Drug_Biologics.pdf). PIs applying to the LCTA are expected to address at least one of the PCRP focus areas and are highly encouraged to address one of the PCRP overarching challenges.

Funding agency

Defense Health Agency Contracting Activity - DHACA
Federal agency

Tags

Healthcare & Biotech Manufacturing Technology & Software Arts & Culture Education & Research Transportation & Logistics Science, Tech & Engineering (STEM)
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Who can apply

Eligibility details aren't on file yet — check the agency source link in the Documents tab for the latest rules.

Geographic eligibility

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Georgia
  • Hawaii
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • North Dakota
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Rhode Island
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming
  • District of Columbia

How to apply

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Source documents

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Canonical NOFO, application packet, and forms
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Citation details

Source systemgrants.gov
Source ID234333
PostedMay 13, 2013

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