DoD Gulf War Illness Investigator-Initiated Research Award — Defense Health Agency Contracting Activity - DHACA funding opportunity
Defense Health Agency Contracting Activity - DHACA · Federal agency

DoD Gulf War Illness Investigator-Initiated Research Award

The GWIRP Investigator-Initiated Research Award was first offered in FY06. Since then, 156 Investigator-Initiated Research Award applications have been received, and 42 have been recommended for funding.The Investigator-...

62
match
Award $0 Deadline 4658 days ago Location Alabama Type grant Level Federal Closed posted May 14, 2013
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Funding amount: total funding pool ~$2,880,000.
  • Next deadline: September 18, 2013.
  • Issued by: Defense Health Agency Contracting Activity - DHACA.
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The “key facts” mode pulls structured fields directly from the official source posting (amount, deadline, eligibility tags). The AI mode adds a short plain-English narrative on top, generated from the same source. Always verify with the agency before applying.

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Award amount
$0
Deadline
4658 days ago
Sep 18, 2013
Total pool
$2.9M

About this opportunity

The GWIRP Investigator-Initiated Research Award was first offered in FY06. Since then, 156 Investigator-Initiated Research Award applications have been received, and 42 have been recommended for funding.The Investigator-Initiated Research Award (IIRA) supports research focusing on the complex of symptoms known as Gulf War Illness, improving its definition and diagnosis, characterizing disease symptoms, and better understanding its pathobiology. It is intended to encourage basic through clinical research aimed at identification of objective measures to distinguish ill from healthy veterans ( biomarkers), elucidate potential treatment targets for GWI, or improve understanding of the pathobiology underlying GWI symptoms. In addition, studies that characterize chronic effects of neurotoxic exposures at dosage comparable to that encountered during the Gulf War are acceptable. Particular areas of interest include research on objective indicators of biological processes or abnormalities in GWI associated with:• Central nervous system structure and function, in particular, the role of glial microglia in GWI symptomatology• Central neuroinflammatory processes• Autonomic nervous system function• Neuroendocrine measures• Immune parameters/Indicators of chronic infection• Gastrointestinal complaints/symptoms• metabolic characteristics• Respiratory symptoms• Sexual dysfunctionThe IIRA provides investigators a mechanism to establish proof of principle for further development in future studies. The IIRA can also be used for testing of GWI-targeted pharmacologic agents in (ADME) studies, and toxicology testing, including Investigational New Drug (IND)-enabling pharmacology/ toxicology testing. Preclinical development of non-pharmacological interventions is also acceptable.The IIRA is designed to promote new ideas in GWI research. Applications are not required to include preliminary data; however, preliminary data may be used to support the objectives of an application. These data are not required to have come from the GWI research field. Applications not supported by preliminary data should be based on a sound scientific rationale and may reflect clinical observations or seek to evaluate GWI discoveries made in relation to other chronic multi-symptom illnesses. Regardless of the approach, the focus should be clearly on ill Gulf War veterans. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly articulate the project’s potential impact on GWI.Applicants proposing clinical research must provide a published case definition they intend to use to define their GWI population. Any case definition must recognize the multi-symptom nature of GWI. PIs proposing studies using animal models should focus on long-term and latent effects of toxic exposures to closely represent the current status of GWI patients. Note: The 2008 report of the Research Advisory Committee on Gulf War Veterans’ Illnesses, Gulf War Illness and the Health of Gulf War Veterans, provides information on GWI case definitions (pp. 29-30, p. 57), previous treatment research in Gulf War veterans (pp. 36-39), and treatment research related to other multi-symptom conditions (pp. 285-287). The report can be found online at: http://www1.va.gov/RAC-GWVI/.Research involving human subjects is permitted under this funding opportunity but is restricted to studies without clinical trials. A clinical trial is defined as a prospective accrual of human subjects where an intervention ( procedure, rehabilitative modality, behavioral intervention or other) is tested on a human subject for ameasurable outcome with respect to exploratory , and/or efficacy. This outcome represents a direct effect on the human subject of that intervention or interaction.

Funding agency

Defense Health Agency Contracting Activity - DHACA
Federal agency

Tags

Healthcare & Biotech Education & Research Veterans Transportation & Logistics Science, Tech & Engineering (STEM)
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Who can apply

Eligibility details aren't on file yet — check the agency source link in the Documents tab for the latest rules.

Geographic eligibility

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Georgia
  • Hawaii
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • North Dakota
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Rhode Island
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming
  • District of Columbia

How to apply

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Source documents

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Citation details

Source systemgrants.gov
Source ID234618
PostedMay 14, 2013

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