DoD Gulf War Illness Investigator-Initiated Research Award — Defense Health Agency Contracting Activity - DHACA funding opportunity
Defense Health Agency Contracting Activity - DHACA · Federal agency

DoD Gulf War Illness Investigator-Initiated Research Award

The GWIRP Investigator-Initiated Research Award (IIRA) was first offered in FY06. Since then, 190 IIRA applications have been received, and 52 have been recommended for funding. New for FY14: The GWIRP IIRA includes a Ca...

99
match
Award $0 Deadline 4286 days ago Location Alabama Type grant Level Federal Closed posted May 7, 2014
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Funding amount: total funding pool ~$6,300,000.
  • Next deadline: September 25, 2014.
  • Issued by: Defense Health Agency Contracting Activity - DHACA.
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The “key facts” mode pulls structured fields directly from the official source posting (amount, deadline, eligibility tags). The AI mode adds a short plain-English narrative on top, generated from the same source. Always verify with the agency before applying.

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Award amount
$0
Deadline
4286 days ago
Sep 25, 2014
Total pool
$6.3M

About this opportunity

The GWIRP Investigator-Initiated Research Award (IIRA) was first offered in FY06. Since then, 190 IIRA applications have been received, and 52 have been recommended for funding. New for FY14: The GWIRP IIRA includes a Case Definition Option, as described below, to encourage applications focused on developing or improving the case definition of GWI for either clinical or research purposes. The IIRA is designed to promote new ideas in GWI research and establish proof of principle for further development in future studies. Applications are not required to include preliminary data; however, preliminary data may be used to support the objectives of an application. These data are not required to have come from the GWI research field. Applications not supported by preliminary data should be based on sound scientific rationale and may reflect clinical observations or seek to evaluate discoveries made in relation to other chronic multi-symptom illnesses for their application in GWI. Regardless of the approach, the focus should be clearly on veterans with GWI. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly articulate the project’s potential impact on GWI. The IIRA supports research focusing on the complex of symptoms known as GWI, improving the case definition and diagnosis of GWI, characterizing disease symptoms, and better understanding the pathobiology. The IIRA encourages basic through clinical research aimed at identification of objective measures ( biomarkers) to distinguish healthy veterans from those with GWI, or improve understanding of the pathobiology underlying symptoms associated with GWI. Particular topic areas of interest include biological processes or abnormalities in GWI associated with: • Central nervous system structure and function, in particular, the role of glial microglia in GWI symptomatology • Central neuroinflammatory processes • Autonomic nervous system function • Neuroendocrine measures • Immune parameters/Indicators of chronic infection • Gastrointestinal complaints/symptoms • metabolic characteristics • Respiratory symptoms • Sexual dysfunction • Sleep Problems • Establishing a GWI case definition Applications may also address other topic areas that are directly relevant to GWI. Studies that characterize chronic effects of neurotoxic exposures at dosages comparable to that encountered in-theatre during the Gulf War are of interest. Studies using animal models should focus on long-term and latent effects of toxic exposures to closely represent the current status of GWI patients. All studies using animal models should use an established model unless there is a compelling scientific justification for the development or use of a new model. Development of new animal models is discouraged. The IIRA can also be used for testing of GWI-targeted pharmacologic agents in (ADME) studies, and toxicology testing, including Investigational New Drug (IND)-enabling pharmacology/ toxicology testing. Preclinical development of non-pharmacological interventions is also acceptable. Case Definition Option: The intent of this option is to support applied research aimed at producing a more robust case definition for GWI for clinical or research applications. Applications submitted under the Case Definition Option will be reviewed separately from all other IIRA applications. Projects appropriate for the Case Definition Option might include analysis of the requirements for clinical and/or research case definitions and their structures, including but not limited to establishing priorities, weighting characteristics, determining exclusionary criteria, and evaluating strategies for dealing with comorbidities.

Funding agency

Defense Health Agency Contracting Activity - DHACA
Federal agency

Tags

Healthcare & Biotech Arts & Culture Education & Research Veterans Transportation & Logistics Science, Tech & Engineering (STEM)
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Who can apply

Eligibility details aren't on file yet — check the agency source link in the Documents tab for the latest rules.

Geographic eligibility

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Georgia
  • Hawaii
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • North Dakota
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Rhode Island
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming
  • District of Columbia

How to apply

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Source documents

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Canonical NOFO, application packet, and forms
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Citation details

Source systemgrants.gov
Source ID254817
PostedMay 7, 2014

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