DoD Tick-Borne Disease, Therapeutic/Diagnostic Research Award — Defense Health Agency Contracting Activity - DHACA funding opportunity
Defense Health Agency Contracting Activity - DHACA · Federal agency

DoD Tick-Borne Disease, Therapeutic/Diagnostic Research Award

The FY22 TBDRP Therapeutic/Diagnostic Research Award is intended to support hypothesis-driven therapeutic and diagnostic development research. Projects submitted under a Treatment Focus Area should be therapeutic evaluat...

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Deadline 1396 days ago Location Alabama Type grant Level Federal Closed posted Apr 11, 2022
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Funding amount: total funding pool ~$4,200,000.
  • Next deadline: August 25, 2022.
  • Issued by: Defense Health Agency Contracting Activity - DHACA.
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The “key facts” mode pulls structured fields directly from the official source posting (amount, deadline, eligibility tags). The AI mode adds a short plain-English narrative on top, generated from the same source. Always verify with the agency before applying.

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Deadline
1396 days ago
Aug 25, 2022
Total pool
$4.2M

About this opportunity

The FY22 TBDRP Therapeutic/Diagnostic Research Award is intended to support hypothesis-driven therapeutic and diagnostic development research. Projects submitted under a Treatment Focus Area should be therapeutic evaluation studies designed to promote new ideas aimed at drug or treatment discovery that are still in the early/preclinical stages of development. Projects submitted under a Diagnosis Focus Area should propose diagnostic approaches that will be readily integrated into clinical settings. All research projects should have a translational potential and aim to improve patient care and/or the quality of life for military Service their beneficiaries, as well as the American public living with Lyme disease and/or other tick-borne diseases.The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited tick-borne disease experience are strongly encouraged to collaborate with experienced tick-borne disease investigators. Applicants with substantial tick-borne disease experience are strongly encouraged to partner with experts in therapeutic and diagnostic assay development and transition, particularly those from the commercial sector. Examples of the types of research that may be supported by this award include, but are not limited to:• Evaluation, maturation, and/or down-selection of potential therapeutic candidates in vitro and/or in vivo• evaluation of proof-of-concept diagnostic assays or devices using in vitro or ex vivo samples• High throughput screening and confirmation of candidate therapeutics obtained from screening or by other means• Testing new therapeutic modalities (agents, delivery mechanisms) using established and accepted preclinical models• Preliminary studies on formulation, stability and safety prior to Good Manufacturing Practice production methods and evaluation in advanced preclinical studies• Investigational New Drug application-enabling studies leading to the development of pharmacologic agents, including compound excretion (ADME) studies, and dose/response and toxicology studies to demonstrate safety and efficacy in relevant model systems• Investigational Device Exemption application-enabling studies leading to the development of devices, including prototype development and device characterization, to demonstrate safety and efficacy using relevant model systems or samples• Optimization and improvement of potential evidence-based treatments or therapeutics for easy administration outside of a clinical setting• Studies aimed at improving diagnostic assay sensitivity, specificity and/or implementation in standard clinical settingsResearch involving human subjects and human anatomical substances is permitted; however, clinical trials are not allowed under this program announcement.Leveraging existing resources, maximizing statistical power, and using validated specimens from Lyme and other tick-borne disease biorepositories and databases are encouraged, but not required. Investigators are strongly encouraged to incorporate the following components into their study design where appropriate: authentication of proposed cell lines; statistical rigor of in vitro cellular studies and preclinical animal experiments; and validation in well-pedigreed cohorts of uniformly documented patients. Studies utilizing data derived from large patient studies that include long-term health records, biospecimen repositories, pre-existing research, and/or studies that apply state-of-the art genomic and/or proteomic analysis, bioinformatics, and/or mathematical models to such data are also encouraged. The criteria defining the inclusion/exclusion of curated biospecimens or data in biorepositories or databases must be described to demonstrate the validity of their use in the proposed studies.A Career Development Option is available to eligible early-career investigators who propose to conduct impactful research under the mentorship of an experienced tick-borne disease researcher.

Funding agency

Defense Health Agency Contracting Activity - DHACA
Federal agency

Tags

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Who can apply

Eligibility details aren't on file yet — check the agency source link in the Documents tab for the latest rules.

Geographic eligibility

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Georgia
  • Hawaii
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • North Dakota
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Rhode Island
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming
  • District of Columbia

How to apply

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Source documents

Source documents available on request
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Citation details

Source systemgrants.gov
Source ID339371
PostedApr 11, 2022

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