Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans — Food and Drug Administration funding opportunity
Food and Drug Administration · Federal agency

Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans

The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit eye and human eye tissue, human skin tissue, or human lung tissue usin...

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Deadline Fixed Location Alabama Type grant Level Federal Open posted May 25, 2021
✦ AI Summary
  • Who can apply: Federal-level applicants (see eligibility for details).
  • Issued by: Food and Drug Administration.
  • About: The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit eye and human eye tissue, human skin tissue, or human lung tissue using most advanced…
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About this opportunity

The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit eye and human eye tissue, human skin tissue, or human lung tissue using most advanced techniques available. Subsequently, the experimental data collected from this study will be implemented into existing modeling platforms to allow for virtual BE assessments locally and systemically for the parent and its pharmacologically active metabolite (for example, prodrugs where it may be important to track both the parent and the active metabolite). Upon the successful completion of this research, it is expected that the implemented enhancements will improve the predictive power of PBPK models that will be utilized to inform decisions on generic orally inhaled drug product development and to perform virtual BE assessments in support of regulatory decisions.

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Citation details

Source systemgrants.gov
Source ID329987
PostedMay 25, 2021

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